Tinnitus neural substrates: an addendum.

Since its initial publication in 1995, the International Tinnitus] ournal (IT J) has been dedicated to providing its readers with state-of-the-art information, not only of basic science but of its integration and translation into clinical medicine for achieving a cure for all clinical types of tinnitus. A report that integrates the clinical and basic science identifying neural substrates and biochemical markers that have been implicated in tinnitus is recognized as a basis for developing drugs for all clinical types of tinnitus. The team at State University of New York (SUNY) Downstate has identified drug development for the tinnitus patient as tinnitopharmacoproteogenomics. Integration and discussion of basic science and clinical reports are essential to progress in drug development for all clinical types of tinnitus for the benefit of the tinnitus patient. The target audience of the IT], both professionals and tinnitus patients, is deserving of state-of-the-art information. The recent publication of J.1. Eggermont's "The Neuroscience of Tinnitus" [I] is a significant contribution to understanding the basic science of the symptom of tinnitus and its clinical application (i.e., translation) for diagnosis and treatment. Unfortunately, the article was not a state-of-the-art reflection of the efforts of professionals involved in both the basic sciences and clinical tinnitus research that have also identified neural substrates involved with tinnitus. The article is considered to be reflective predominantly of basic science and academic efforts limited to neural substrates identified in animal experimentation. The article has omissions that render it incomplete and not reflective of the current state of the art for clinical investigations. In general, concepts developed particularly from tinnitus patient research in clinical medicine have been translated into hypotheses that have contributed to the interpretation of findings of neural substrates in tinnitus patients since 1979 at SUNY Downstate. Our team has considered that the interpretation of tinnitus neural substrate data in experimental animals and tinnitus patients embodies certain elements.